Microorganisms for ginsenosides biosynthesis: recent progress, challenges, and perspectives

LL Chu, NQ Huy, NH Tung - Molecules, 2023 - mdpi.com
Ginsenosides are major bioactive compounds present in the Panax species. Ginsenosides
exhibit various pharmaceutical properties, including anticancer, anti-inflammatory …

Biosynthesis and biotechnological production of the anti-obesity agent celastrol

Y Zhao, NL Hansen, YT Duan, M Prasad… - Nature Chemistry, 2023 - nature.com
Obesity is a major health risk still lacking effective pharmacological treatment. A potent anti-
obesity agent, celastrol, has been identified in the roots of Tripterygium wilfordii. However …

[HTML][HTML] Celastrol: A century-long journey from the isolation to the biotechnological production and the development of an antiobesity drug

Y Zhao, K Miettinen, SC Kampranis - Current Opinion in Plant Biology, 2024 - Elsevier
Celastrol, a triterpenoid found in the root of the traditional medicinal plant Tripterygium
wilfordii, is a potent anti-inflammatory and antiobesity agent. However, pharmacological …

Efficient production of 22(R)‐hydroxycholesterol via combination optimization of Saccharomyces cerevisiae

Y Pang, X Cheng, Y Ban, Y Li, B Lv… - Biotechnology …, 2024 - Wiley Online Library
Abstract 22 (R)‐hydroxycholesterol (22 (R)‐HCHO) is a crucial precursor of steroids
biosynthesis with various biological functions. However, the production of 22 (R)‐HCHO is …

Research overview on sugarcane deep processing and comprehensive utilization in China

GL Chen, J Chen, B Lin, LZ Zhao, FJ Zheng, KK Verma… - Sugar Tech, 2024 - Springer
The sugar industry is important for the economic development in China. Guangxi province is
the largest sugar producer with over 60% of the total sugarcane cultivating area in the …

Herbal Multiomics Provide Insights into Gene Discovery and Bioproduction of Triterpenoids by Engineered Microbes

F Zhang, X Hao, J Liu, H Hou, S Chen… - Journal of Agricultural …, 2024 - ACS Publications
Triterpenoids are natural products found in plants that exhibit industrial and agricultural
importance. Triterpenoids are typically synthesized through two main pathways: the …

[HTML][HTML] Cultivation optimization promotes ginsenoside and universal triterpenoid production by engineered yeast

S Qiu, MDS Gilani, C Müller, RM Zarazua-Navarro… - New …, 2024 - Elsevier
Ginseng, a cornerstone of traditional herbal medicine in Asia, garnered significant attention
for its therapeutic potential. Central to its pharmacological effects are ginsenosides, the …

Sustainable production of natural products using synthetic biology: Ginsenosides

SH Son, J Kang, YJ Shin, CY Lee, BH Sung… - Journal of Ginseng …, 2024 - Elsevier
Synthetic biology approaches offer potential for large-scale and sustainable production of
natural products with bioactive potency, including ginsenosides, providing a means to …

[引用][C] 萜类化合物高效发现与产业化制造

池豪铭, 鄂丽影, 刘天罡 - 中国科学院院刊, 2025