Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

The compartmentalization of eukaryotic cells is reliant on the fidelity of vesicle-mediated
intracellular transport. Vesicles deliver their cargo via membrane fusion, a process requiring …

Lysosomes are essential for cellular recycling, nutrient signaling, autophagy, and
pathogenic bacteria and viruses invasion. Lysosomal fusion is fundamental to cell survival …

The key endosomal regulators Rab5, EEA1, and APPL1 are frequently applied in
fluorescence microscopy to mark early endosomes, whereas Rab7 is used as a marker for …

Autophagy is a constitutive cellular process of degradation required to maintain homeostasis
and turn over spent organelles and aggregated proteins. For some viruses, the process can …

The multisubunit HOPS tethering complex is a well-established regulator of lysosome fusion
with late endosomes and autophagosomes. However, the role of the HOPS complex in other …

Cargo delivery from one compartment to the next relies on the fusion of vesicles with
different cellular organelles in a process that requires the concerted action of tethering …

Abstract The Conserved Oligomeric Golgi (COG) complex, a multi-subunit vesicle tethering
complex of the CATCHR (Complexes Associated with Tethering Containing Helical Rods) …

The inefficient translocation of proteins across biological membranes limits their application
as potential therapeutics and research tools. In many cases, the translocation of a protein …

Membrane fusion requires R-, Qa-, Qb-, and Qc-family SNAREs that zipper into RQaQbQc
coiled coils, driven by the sequestration of apolar amino acids. Zippering has been thought …