Systemic cytotoxic (anti-proliferative) anticancer drugs rely primarily for their therapeutic
effect on cytokinetic differences between cancer and normal cells. One approach aimed at …

Anticancer prodrugs designed to target specifically tumor cells should increase therapeutic
effectiveness and decrease systemic side effects in the treatment of cancer. Over the last 20 …

Anticancer drugs are primarily cytotoxic agents, and exert their antitumor activity by
interfering with some aspects of DNA replication, repair, translation, or cell division. Hence …

Acridine derivatives have been actively researched over the years as prospective
therapeutic agents for a wide range of disorders, including cancer, Alzheimer's disease and …

Efficient extravascular diffusion is a critical requirement for hypoxic cell radiosensitisers,
bioreductive drugs and hypoxic cell markers that must reach cells distant from functional …

Hypoxic-specific cytotoxins are a new, and as yet clinically untested, mode of treatment of
solid tumors. If they can be given at high enough concentrations and sufficiently often, they …

A new in vitro model has been developed for investigating extravascular diffusion of
therapeutic agents in tumour tissue. V79-171b or EMT6/Ak cells are grown on porous Teflon …

Nitroaniline mustardshave potential as hypoxia-selective cytotoxic agents, with reductive
metabolism activating the nitrogen mustard by converting the electron-withdrawing nitro …

Abstract SR 4233 (3-amino-1, 2, 4-benzotriazine 1, 4-dioxide) is the lead compound in a
series of benzotriazine di-N-oxides which exhibit high selective killing of hypoxic …

Acridine derivatives show a broad range of biological activities. They have primarily been
explored as chemotherapeutic agents (anticancer, antibacterial, antiprotozoal), because of …