Bioactive materials are a special class of biomaterials that can react in vivo to induce a
biological response or regulate biological functions, thus achieving a better curative effect …

Arsenic is a naturally occurring metalloid and one of the few metals that can be metabolized
inside the human body. The pervasive presence of arsenic in nature and anthropogenic …

Acute myeloid leukemia (AML) is a cancer of myeloid-lineage cells with limited therapeutic
options. We previously combined ex vivo drug sensitivity with genomic, transcriptomic, and …

The implementation of targeted therapies for acute myeloid leukaemia (AML) has been
challenging because of the complex mutational patterns within and across patients as well …

Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

In 1957, Hillestad et al. defined acute promyelocytic leukemia (APL) for the first time in the
literature as a distinct type of acute myeloid leukemia (AML) with a “rapid downhill course” …

The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …

Background All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for
acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of …

Background Acute promyelocytic leukaemia is a chemotherapy-sensitive subgroup of acute
myeloid leukaemia characterised by the presence of the PML–RARA fusion transcript. The …

Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the
gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals …