Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …

The Vitamins: Fundamental Aspects in Nutrition and Health, Fifth Edition, provides the latest
coverage of the biochemistry and physiology of vitamins and vitamin-like substances. Health …

Vitamin E is an important antioxidant that primarily protects cells from damage associated
with oxidative stress caused by free radicals. The brain is highly susceptible to oxidative …

Background Genome-wide association studies of Alzheimer's disease (AD) have implicated
pathways related to lipid homeostasis and innate immunity in AD pathophysiology …

The APOE gene is one of currently only two genes that have consistently been associated
with longevity. Apolipoprotein E (APOE) is a plasma protein which plays an important role in …

Vitamin E (VE) has a recognized leading role as a contributor to the protection of cell
constituents from oxidative damage. However, evidence suggests that the health benefits of …

Vitamin E modulates the activity of several signal transduction enzymes with consequent
alterations of gene expression. At the molecular level, vitamin E may directly bind to these …

COVID-19 incidence and case fatality rates (CFR) differ among ethnicities, stimulating efforts
to pinpoint genetic factors that could explain these phenomena. In this regard, the …

The classical amyloid cascade model for Alzheimer's disease (AD) has been challenged by
several findings. Here, an alternative molecular neurobiological model is proposed. It is …