Biological significance of the protein changes occurring in the cerebrospinal fluid of alzheimer's disease patients: Getting clues from proteomic studies
CM Pedrero-Prieto, J Frontiñán-Rubio, FJ Alcaín… - Diagnostics, 2021 - mdpi.com
The fact that cerebrospinal fluid (CSF) deeply irrigates the brain together with the relative
simplicity of sample extraction from patients make this biological fluid the best target for …
simplicity of sample extraction from patients make this biological fluid the best target for …
Updates on the study of lysosomal protein dynamics: possibilities for the clinic
D Arora, Y Hackenberg, J Li… - Expert Review of …, 2023 - Taylor & Francis
Introduction The lysosome is the main degradative organelle of almost all mammalian cells,
fulfilling important functions in macromolecule recycling, metabolism, and signaling …
fulfilling important functions in macromolecule recycling, metabolism, and signaling …
Large‐scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease
INTRODUCTION A hallmark of Alzheimer's disease (AD) is the aggregation of proteins
(amyloid beta [A] and hyperphosphorylated tau [T]) in the brain, making cerebrospinal fluid …
(amyloid beta [A] and hyperphosphorylated tau [T]) in the brain, making cerebrospinal fluid …
Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease implicates mediation through GPX3
The recently reported TNIP1/GPX3 locus from AD GWAS studies was investigated. Using
proteomics and other functional omics data, we identified evidence for a functional …
proteomics and other functional omics data, we identified evidence for a functional …
[图书][B] CSF biomarker panels. Focus on synaptic pathology
J Nilsson - 2022 - gupea.ub.gu.se
Fluid biomarkers of neuropathological features are important clinical tools in diagnostics and
patient monitoring of neurodegenerative diseases. For the most prevalent cause of …
patient monitoring of neurodegenerative diseases. For the most prevalent cause of …
Large-scale proteome and metabolome analysis of CSF implicates altered glucose metabolism and succinylcarnitine in Alzheimer's disease
A major hallmark of Alzheimer's disease (AD) is the aggregation of misfolded proteins (β-
amyloid (A) and hyperphosphorylated tau (T)) in the brain. As these proteins can be …
amyloid (A) and hyperphosphorylated tau (T)) in the brain. As these proteins can be …