In Alzheimer's disease, post-mortem studies have shown that the first cortical site where
neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial …

Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive
decline in Alzheimer's disease and related dementias. Our knowledge of the pattern of …

The medial temporal lobe (MTL) is a nidus for neurodegenerative pathologies and therefore
an important region in which to study polypathology. We investigated associations between …

Postmortem MRI allows brain anatomy to be examined at high resolution and to link
pathology measures with morphometric measurements. However, automated segmentation …

Ex vivo MRI of the brain provides remarkable advantages over in vivo MRI for visualizing
and characterizing detailed neuroanatomy. However, automated cortical segmentation …

Neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to
neurodegeneration, and is the early pathological change associated with Alzheimer's …

Tau protein neurofibrillary tangles (NFT) are closely linked to neuronal/synaptic loss and
cognitive decline in Alzheimer's disease (AD) and related dementias. Our knowledge of the …

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) and tau depositions as well as
neurodegeneration, and is typically accompanied by a progressive decline in episodic …