Ever since its discovery by Windhaus, the importance of the active metabolite of vitamin D (1,
25-dihydroxyvitamin D3; 1, 25-(OH) 2D3) has been ever expanding. In this review, the …

Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease.
Both represent chronic inflammation of the gastrointestinal tract, which displays …

Microbe–host communication is essential to maintain vital functions of a healthy host, and its
disruption has been associated with several diseases, including Crohn's disease and …

The classical functions of vitamin D are to regulate calcium-phosphorus homeostasis and
control bone metabolism. However, vitamin D deficiency has been reported in several …

Background & Aims Multiple environmental factors have been associated with the
development of inflammatory bowel diseases (IBDs). We performed an umbrella review of …

Over the last three decades, it has become clear that the role of vitamin D goes beyond the
regulation of calcium homeostasis and bone health. An important extraskeletal effect of …

(1) Background: Vitamin D is an immunoregulatory factor influencing intestinal homeostasis.
Recent evidence supports a central role of this micronutrient in the course of Inflammatory …

Sarcopenia represents a major health burden in industrialized country by reducing
substantially the quality of life. Indeed, it is characterized by a progressive and generalized …

The immune system, innate and adaptive, is a highly evolved and complex network,
essential for promoting survival in an environment full of potential pathogens, while …

The vitamin D receptor is expressed in multiple cells of the body (other than osteoblasts),
including beta cells and cells involved in immune modulation (such as mononuclear cells …