Chronic obstructive pulmonary disease (COPD) is significant cause of morbidity and
mortality worldwide. There is mounting evidence suggesting that COPD patients are at …

Oxidative stress is a major hallmark of COPD, contributing to inflammatory signaling,
corticosteroid resistance, DNA damage, and accelerated lung aging and cellular …

Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and
infective exacerbations, however, in-vitro model systems for the study of host-pathogen …

Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded
RNA viruses, and is increased in both human and cigarette smoke (CS)-induced …

The human airway mucociliary epithelium can be recapitulated in vitro using primary cells
cultured in an air–liquid interface (ALI), a reliable surrogate to perform pathophysiological …

Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition.
Objectives: We hypothesized that the unbiased integration of different COPD lung omics …

Cathepsin B (CTSB) is a member of the cysteine protease family, primarily responsible for
degrading unnecessary organelles and proteins within the acidic milieu of lysosomes to …

COPD poses a significant global public health challenge, primarily characterised by
irreversible airflow restriction and persistent respiratory symptoms. The hallmark pathology …

Background/Objective: Little is known about the impact of the COVID-19 pandemic on
mortality from COPD at the population level. The objective was to investigate COPD-related …

Rationale: IL-33 is a proinflammatory cytokine thought to play a role in the pathogenesis of
asthma and chronic obstructive pulmonary disease (COPD). A recent clinical trial using an …