Adjuvants: Classification, Modus Operandi, and Licensing

JS Apostolico, VAS Lunardelli… - Journal of …, 2016 - Wiley Online Library
Vaccination is one of the most efficient strategies for the prevention of infectious diseases.
Although safer, subunit vaccines are poorly immunogenic and for this reason the use of …

Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens

Y Perrie, AR Mohammed, DJ Kirby, SE McNeil… - International journal of …, 2008 - Elsevier
Vaccination remains a key tool in the protection and eradication of diseases. However, the
development of new safe and effective vaccines is not easy. Various live organism based …

[图书][B] Chitin, chitosan, oligosaccharides and their derivatives: biological activities and applications

SK Kim - 2010 - books.google.com
Providing comprehensive coverage of the biological activities and industrial applications of
Chitin, Chitosan, oligosaccharides, and their derivatives, this book presents a balance of …

New insights in mucosal vaccine development

V Pavot, N Rochereau, C Genin, B Verrier, S Paul - Vaccine, 2012 - Elsevier
Mucosal surfaces are the major entrance for infectious pathogens and therefore mucosal
immune responses serve as a first line of defence. Most current immunization procedures …

Nanotechnology solutions for mucosal immunization

S Chadwick, C Kriegel, M Amiji - Advanced drug delivery reviews, 2010 - Elsevier
The current prevalence of infectious diseases in many developing regions of the world is a
serious burden, impacting both the general health as well as economic growth of these …

Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies

S Wang, H Liu, X Zhang, F Qian - Protein & cell, 2015 - academic.oup.com
Most pathogens initiate their infections at the human mucosal surface. Therefore, mucosal
vaccination, especially through oral or intranasal administration routes, is highly desired for …

Bis-(3′, 5′)-cyclic dimeric adenosine monophosphate: strong Th1/Th2/Th17 promoting mucosal adjuvant

T Ebensen, R Libanova, K Schulze, T Yevsa, M Morr… - Vaccine, 2011 - Elsevier
New effective adjuvants are required to improve the performance of subunit vaccines. Here,
we showed that bis-(3′, 5′)-cyclic dimeric adenosine monophosphate (c-di-AMP), a …

Strategies for intranasal delivery of vaccines

M Zaman, S Chandrudu, I Toth - Drug delivery and translational research, 2013 - Springer
The vast majority of human pathogens colonize and invade at the mucosal surfaces.
Preventing infection at these sites via mucosally active vaccines is a promising and rational …

Carbohydrate immune adjuvants in subunit vaccines

S Bashiri, P Koirala, I Toth, M Skwarczynski - Pharmaceutics, 2020 - mdpi.com
Modern subunit vaccines are composed of antigens and a delivery system and/or adjuvant
(immune stimulator) that triggers the desired immune responses. Adjuvants mimic pathogen …

Chitosan-based delivery systems for mucosal vaccines

I Jabbal-Gill, P Watts, A Smith - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: Mucosal vaccine development faces several challenges and opportunities.
Critical issues for effective mucosal vaccination include the antigen-retention period that …