Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes
MJ Topper, JW Guarnieri, JA Haltom… - Proceedings of the …, 2024 - pnas.org
Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using
RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying of SARS …
RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying of SARS …
SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19
JW Guarnieri, JA Haltom, YES Albrecht, T Lie… - Pharmacological …, 2024 - Elsevier
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an
exhaustive survey of the cellular metabolic pathways modulated by SARS-CoV-2 infection …
exhaustive survey of the cellular metabolic pathways modulated by SARS-CoV-2 infection …
Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination
ZYG11B is a substrate specificity factor for Cullin-RING ubiquitin ligase (CRL2) involved in
many biological processes, including Gly/N-degron pathways. Yet how the binding of …
many biological processes, including Gly/N-degron pathways. Yet how the binding of …
A pan-tissue, pan-disease compendium of human orphan genes
Species-specific genes are ubiquitous in evolution, with functions ranging from prey
paralysis to survival in subzero temperatures. Because they are typically expressed under …
paralysis to survival in subzero temperatures. Because they are typically expressed under …