Microalgae for the production of lipid and carotenoids: a review with focus on stress regulation and adaptation

XM Sun, LJ Ren, QY Zhao, XJ Ji, H Huang - Biotechnology for biofuels, 2018 - Springer
Microalgae have drawn great attention as promising sustainable source of lipids and
carotenoids. Their lipid and carotenoids accumulation machinery can be trigged by the …

Adaptive laboratory evolution–principles and applications for biotechnology

M Dragosits, D Mattanovich - Microbial cell factories, 2013 - Springer
Adaptive laboratory evolution is a frequent method in biological studies to gain insights into
the basic mechanisms of molecular evolution and adaptive changes that accumulate in …

Constraining the metabolic genotype–phenotype relationship using a phylogeny of in silico methods

NE Lewis, H Nagarajan, BO Palsson - Nature Reviews Microbiology, 2012 - nature.com
Reconstructed microbial metabolic networks facilitate a mechanistic description of the
genotype–phenotype relationship through the deployment of constraint-based …

Network context and selection in the evolution to enzyme specificity

H Nam, NE Lewis, JA Lerman, DH Lee, RL Chang… - Science, 2012 - science.org
Enzymes are thought to have evolved highly specific catalytic activities from promiscuous
ancestral proteins. By analyzing a genome-scale model of Escherichia coli metabolism, we …

Engineering furfural tolerance in Escherichia coli improves the fermentation of lignocellulosic sugars into renewable chemicals

X Wang, LP Yomano, JY Lee… - Proceedings of the …, 2013 - National Acad Sciences
Pretreatments such as dilute acid at elevated temperature are effective for the hydrolysis of
pentose polymers in hemicellulose and also increase the access of enzymes to cellulose …

Adaptive evolution of Schizochytrium sp. by continuous high oxygen stimulations to enhance docosahexaenoic acid synthesis

XM Sun, LJ Ren, XJ Ji, SL Chen, DS Guo… - Bioresource …, 2016 - Elsevier
Adaptive laboratory evolution (ALE) is an effective method in changing the strain
characteristics. Here, ALE with high oxygen as a selection pressure was applied to improve …

Adaptive evolution of Schizochytrium sp. under light and H2O2 condition to regulate its fatty acid and terpene biosynthesis

R Zhang, Y Luo, X Yu, M Dang, X Hu, L Ren - Algal Research, 2023 - Elsevier
Schizochytrium sp. is an important marine microalga rich in polyunsaturated fatty acids. As
an oleaginous marine microorganism, Schizochytrium sp. can accumulate different high …

Application of microalgal stress responses in industrial microalgal production systems

J Wang, Y Wang, Y Wu, Y Fan, C Zhu, X Fu, Y Chu… - Marine Drugs, 2021 - mdpi.com
Adaptive laboratory evolution (ALE) has been widely utilized as a tool for developing new
biological and phenotypic functions to explore strain improvement for microalgal production …

Induction of resistance mechanisms in Rhodotorula toruloides for growth in sugarcane hydrolysate with high inhibitor content

HJS Lopes, N Bonturi, EA Miranda - Applied Microbiology and …, 2021 - Springer
The oleaginous yeast Rhodotorula toruloides is a potential lipid producer for biodiesel
production. However, this yeast shows growth inhibition due to harmful compounds when …

Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping

M Kitsak, A Ganin, A Elmokashfi, H Cui… - Nature …, 2023 - nature.com
Dynamic processes on networks, be it information transfer in the Internet, contagious
spreading in a social network, or neural signaling, take place along shortest or nearly …