The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia
While germline and somatic mutations in the gene PTPN11, encoding a phosphatase which
regulates the RAS signaling pathway, are well characterized in children with Noonan …
regulates the RAS signaling pathway, are well characterized in children with Noonan …
A patent review of RAF kinase inhibitors (2010–2018)
RJ Man, YL Zhang, AQ Jiang… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: RAF kinase inhibitors block and regulate RAS/RAF/MEK/ERK signaling, which
is a key to tumor treatment. At present, although RAF kinase inhibitors have good efficacy …
is a key to tumor treatment. At present, although RAF kinase inhibitors have good efficacy …
A patent review of BRAF inhibitors: 2013-2018
PF Wang, HY Qiu, HL Zhu - Expert Opinion on Therapeutic Patents, 2019 - Taylor & Francis
Introduction: As a key element in arguably the most important pathway MAPK signaling, the
BRAF kinase gives rise to severe diseases including cancers when pathologically activated …
BRAF kinase gives rise to severe diseases including cancers when pathologically activated …