Hemorrhagic shock (HS) management is based on a timely, rapid, definitive source control
of bleeding/s and on blood loss replacement. Stopping the hemorrhage from progressing …

The microvasculature plays a central role in the pathophysiology of hemorrhagic shock and
is also involved in arguably all therapeutic attempts to reverse or minimize the adverse …

The endothelial glycocalyx plays an essential role in many physiological functions and is
damaged after hemorrhage. Fluid resuscitation may further change the glycocalyx after an …

Background: Increased microcirculatory flow and perfusion has been reported to improve
clinical outcomes following shock. The optimal resuscitation fluid to restore the flow …

A shift of approach from 'clinics trying to fit physiology'to the one of 'physiology to clinics', with
interpretation of the clinical phenomena from their physiological bases to the tip of the …

Background Fluid resuscitation in hemorrhagic shock aims to restore hemodynamics and
repair altered microcirculation. Hemodynamic coherence is the concordant performance of …

Normal shear stress is essential for the normal structure and functions of the
microcirculation. Hemorrhagic shock leads to reduced shear stress due to reduced tissue …

Microcirculatory preservation is essential for patient recovery from hemorrhagic shock. In
hemorrhagic shock, microcirculatory flow and pressure are greatly reduced, creating an …

The development of an alternative to blood transfusion to treat severe hemorrhage remains
a challenge, especially in far forward scenarios when blood is not available. Hemoglobin …

The ultimate goal of fluid therapy is to improve the oxygenation of cells by improving the
cardiac output, thus improving microcirculation by optimizing macrocirculation. This …