Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the
present time is widely accepted as an alternative treatment for cancer. In this review, we …

The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

Silibinin, a natural flavanone, derived from the milk thistle plant (Silybum marianum), was
illustrated for several medicinal uses such as liver-protective, anti-oxidant, anti-cancer, anti …

Silibinin (SIL) is a natural polyphenolic flavonoid with multiple biological and anti-cancer
features. However, the complex hydrophobic nature and inadequate bioavailability of SIL …

The evolving concept that cancer stem cells (CSCs) are the driving element in cancer
development, evolution and heterogeneity, has overridden the previous model of a tumor …

Although malignant phenotypes of triple-negative breast cancer (TNBC) are subject to
circadian alterations, the role of cancer stem cells (CSC) in defining this circadian change …

Chemotherapeutic agents are commonly used as neoadjuvant for breast cancer therapy.
However, there is evidence of treatment failure for most of patients due to acquired …

Purpose: The failure of chemotherapy in breast cancer is caused by breast cancer stem cells
(BCSCs), a minor population of cells in bulk mammary tumors. Previously, hesperetin, a …

Breast cancer therapy with classical chemotherapy is unable to eradicate breast cancer
stem cells (BCSCs). Loss of p53 function causes growth and differentiation in cancer stem …

The potential anti-cancer properties of natural plant compounds have elicited widespread
interest in recent times since it is believed that they can substantially contribute to the …