The identification of interactions between drugs/compounds and their targets is crucial for
the development of new drugs. In vitro screening experiments (ie bioassays) are frequently …

A few decades ago, drug discovery and development were limited to a bunch of medicinal
chemists working in a lab with enormous amount of testing, validations, and synthetic …

The identification of drug/compound–target interactions (DTIs) constitutes the basis of drug
discovery, for which computational predictive approaches have been developed. As a …

Proteochemometric (PCM) modelling is a computational method to model the bioactivity of
multiple ligands against multiple related protein targets simultaneously. Hence it has been …

Research on the immune system and cancer has led to the development of new medicines
that enable the former to attack cancer cells. Drugs that specifically target and destroy …

Potassium channels participate in many critical biological functions and play important roles
in a variety of diseases. In recent years, many significant discoveries have been made which …

Abstract Background The rhizome of Hydnophytum formicarum Jack., a medicinal plant
known in Thai as Hua-Roi-Roo, has been used in Thai traditional herbal medicine for …

Objective Valproic acid (VA) is a histone deacetylase (HDAC) inhibitor that has
antiproliferative effects on several types of cancer, including thyroid cancer. In addition, VA …

Targeted therapy pinpointing specific alteration in cancer cells has gained an important role
in the treatment of cancer. Compounds that re-induce thyroid-specific functions could be …

Cancer is considered as one of the world's leading causes of morbidity and mortality. Over
the past four decades, spectacular advances in molecular and cellular biology have led to …