Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

Based on the reports reviewed in here, targeting of the renal endothelin system is a possible
therapeutic approach against the development of glomerular injury. More animal and clinical …

Aldosterone exerts profound effects on renal and cardiovascular physiology. In the kidney,
aldosterone acts to preserve electrolyte and acid-base balance in response to changes in …

The circadian clock is integral to the maintenance of daily rhythms of many physiological
outputs, including blood pressure. Our laboratory has previously demonstrated the …

The impact of circadian rhythms on cardiovascular function and disease development is well
established, with numerous studies in genetically modified animals emphasizing the …

Background Premenopausal women are less likely to develop hypertension and salt‐related
complications than are men, yet the impact of sex on mechanisms regulating Na+ …

Premenopausal women generally exhibit lower blood pressure and a lower prevalence of
hypertension than men of the same age, but these differences reverse postmenopause due …

Recent studies suggested a direct link between circadian rhythms and regulation of sodium
excretion. Endothelin-1 (ET-1) regulates sodium balance by promoting natriuresis through …

Highlights•Circadian rhythms are important for cardiovascular physiology; disturbing
rhythms causes adverse cardiovascular consequences.•Circadian medicine is a new frontier …

Highlights•The endothelin system is a critical renal regulator of salt and water
homeostasis.•Renal ET B receptor function is impaired in hypertensive males.•Endothelin …