The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Photobiomodulation (otherwise known as low level light therapy) is an emerging approach
for treating many diseases and conditions such as pain, inflammation, wound healing, brain …

Pathological sensations caused by peripheral painful neuropathy occurring in Type 2
diabetes mellitus (T2DM) are often described as 'sharp'and 'burning'and are commonly …

Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment
of neuropathic pain. The analgesia lasts for several months after a single treatment …

Long-term potentiation in the spinal dorsal horn requires peptidergic C-fibre activation in
animals. Perceptual correlates of long-term potentiation following high-frequency electrical …

Rodents are the main model systems for pain research, but determining their pain state is
challenging. To develop an objective method to assess pain sensation in mice, we adopt …

A fundamental subdivision of nociceptive sensory neurons is named after their unique
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …

Disorders of pain neural systems are frequently chronic and, when recalcitrant to treatment,
can severely degrade the quality of life. The pain pathway begins with sensory neurons in …

The most common medicinal claims for cannabis are relief from chronic pain, stimulation of
appetite, and as an antiemetic. However, the mechanisms by which cannabis reduces pain …

Inherited painless neuropathies arise due to genetic insults that either block the normal
signaling of or destroy the sensory afferent neurons in the dorsal root ganglion (DRG) …