The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

Human endogenous retroviruses (hERVs) are remnants of exogenous retroviruses that have
integrated into the genome throughout evolution. We developed a computational workflow …

Changes in human DNA methylation patterns are an important feature of cancer
development and progression and a potential role in other conditions such as …

Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of …

DNA and histone methylation are linked and subjected to mitotic inheritance in mammals.
Yet how methylation is propagated and maintained between successive cell divisions is not …

Extracellular membrane vesicles (EMVs) are nanometer sized vesicles, including exosomes
and microvesicles capable of transferring DNAs, mRNAs, microRNAs, non-coding RNAs …

Recent findings have demonstrated the aberrant DNA methylation of the Nrf2-Keap1 genes
in human cancers; however, the epigenetic control of this pathway in non-alcoholic fatty liver …

Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …

We analyze transposable elements (TEs) in glioblastoma (GBM) patients using a
proteogenomic pipeline that combines single-cell transcriptomics, bulk RNA sequencing …