Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

The disorder of lipid metabolism is pathologically linked to hyperlipidemia, lipid storage
disease, obesity and other related diseases. Intriguingly, recent studies have revealed that …

Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Background Metabolic disorders are a hallmark feature of cancer. However, the evidence for
the causality of circulating metabolites to promote or prevent colorectal cancer (CRC) is still …

Background Increasing evidence suggests that high-density lipoprotein (HDL) may play a
role in cancer development. We tested the hypothesis that low HDL levels are associated …

Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

The vast majority of research about HDL (high-density lipoprotein) has for decades revolved
around the possible role of HDL in atherosclerosis and its therapeutic potential within …

Background Epidemiological studies have linked lifestyle, cardiometabolic, reproductive,
developmental, and inflammatory factors to the risk of colorectal cancer. However, which …

Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this
relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic …

The relationship between high-density lipoproteins (HDLs), HDL-cholesterol (HDLsingle
bond C) and cancer incidence and mortality is controversial. Although most studies …