Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Amyotrophic lateral sclerosis (ALS) is a neural disorder that causes death of the motor
neurons in the brain and spinal cord; this affects the voluntary muscles and gradually leads …

We perform a large-scale meta-analysis of 51 peer-reviewed 3xTg-AD mouse publications
to compare Alzheimer's disease (AD) quantitative clinical outcome measures, including …

Defective axonal transport is an early neuropathological feature of amyotrophic lateral
sclerosis (ALS). We have previously shown that ALS-associated mutations in Cu/Zn …

The amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized
by motoneurons death. Mutations in the superoxide dismutase 1 (SOD1) protein have been …

Background: The complex and not yet fully understood etiology of Alzheimer's disease (AD)
shows important proteopathic signs which are unlikely to be linked to a single protein …

Oxidative stress, induced by an imbalance of free radicals, incites neurodegeneration in
Amyotrophic Lateral Sclerosis (ALS). In fact, a mutation in antioxidant enzyme superoxide …

Background: Recent studies have suggested overlapping pathological features among
motor neuron, cognitive and neurodegenerative diseases. Aims/Methods: Secondary …

Multiple studies have shown that antecedent diseases are less prevalent in amyotrophic
lateral sclerosis (ALS) patients than the general age-matched population, which suggests …

Objective: The heterogeneity of amyotrophic lateral sclerosis (ALS) survival duration, which
varies from< 1 year to> 10 years, challenges clinical decisions and trials. Utilizing data from …