Cellular associations in the bone microenvironment are involved in modulating the balance
between bone remodeling and resorption, which is necessary for maintaining a normal bone …

Herbal medicines have long been used as a traditional mode of therapy for various ailments
in India. They are being used increasingly as dietary supplements to ward off common …

Tumour metastasis is a complex process involving reciprocal interplay between cancer cells
and host stroma at both primary and secondary sites, and is strongly influenced by …

Osteoclasts are cells derived from bone marrow macrophages and are important in
regulating bone resorption during bone homeostasis. Understanding what drives osteoclast …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

NF-kappa B is a ubiquitous transcription factor. Nevertheless, its properties seem to be most
extensively exploited in cells of the immune system. Among these properties are NF-kappa …

Rationale: Growing evidence indicates that intracellular reactive oxygen species (ROS)
accumulation is a critical factor in the development of osteoporosis by triggering osteoclast …

Periodontitis is a term used to describe an inflammatory process, initiated by the plaque
biofilm, that leads to loss of periodontal attachment to the root surface and adjacent alveolar …

Redox (oxidation-reduction) reactions regulate signal transduction. Oxidants such as
superoxide, hydrogen peroxide, hydroxyl radicals, and lipid hydroperoxides (ie, reactive …

The pathological events leading to the destruction of the periodontium during inflammatory
periodontal diseases are likely to represent complex interactions involving an imbalance in …