The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …

Background Why some individuals develop AIDS rapidly whereas others remain healthy
without treatment for many years remains a central question of HIV research. Of the …

Although host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-
mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here …

HIV virulence, ie the time of progression to AIDS, varies greatly among patients. As for other
rapidly evolving pathogens of humans, it is difficult to know if this variance is controlled by …

Several studies have shown that cytotoxic T lymphocytes (CTLs) play an important role in
controlling HIV/SIV infection. Notably, the observation of escape mutants suggests a …

Lamivudine therapy selects for the M184V mutation. Although this mutation reduces the
replicative capacity of human immunodeficiency virus in vitro, its impact on viral fitness in …

Hepatitis B virus (HBV) infection is a major global health problem with over 240 million
infected individuals at risk of developing progressive liver disease and hepatocellular …

Viral infections cause substantial morbidity and mortality in transplant patients. Quantifying
viral loads is widely appreciated as a direct means to diagnose and monitor the course of …

Although CD8+ T cells play an important role in controlling viral infections, boosting specific
CD8+ T cells by prophylactic vaccination with simian immunodeficiency virus (SIV) epitopes …

Patients infected with HIV exhibit orders of magnitude differences in their set-point levels of
the plasma viral load. As to what extent this variation is due to differences in the efficacy of …