The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic
adaptor proteins regulate the signal transduction pathways of a variety of receptors …

Copy number variations (CNVs) which include deletions, duplications, inversions,
translocations, and other forms of chromosomal re-arrangements are common to human …

Motivation Structural variation, including large deletions, duplications, inversions,
translocations and other rearrangements, is common in human and cancer genomes. A …

Background Postzygotic de novo mutations lead to the phenomenon of gene mosaicism.
The 3 main types are called somatic, gonadal, and gonosomal mosaicism, which differ in …

The era of whole-genome sequencing has revealed that gene copy-number changes
caused by duplication and deletion events have important evolutionary, functional, and …

Complex genomic rearrangements (CGRs) are emerging as a new feature of cancer
genomes. CGRs are characterized by multiple genomic breakpoints and thus have the …

Identifying driver mutations and their functional consequences is critical to our
understanding of cancer. Towards this goal, and because domains are the functional units of …

Background Diffuse astrocytomas are the most common type of primary brain cancer in
adults. They present a wide variation in differentiation and aggressiveness, being classified …

Transcripts are frequently modified by structural variations, which lead to fused transcripts of
either multiple genes, known as a fusion gene, or a gene and a previously non-transcribed …

About half of the known miRNA genes are located within protein-coding host genes, and are
thus subject to co-transcription. Accumulating data indicate that this coupling may be an …