Unique functions of specialised cells such as those of the immune and haemostasis
systems, skin, blood vessels, lung, and bone require specialised compartments, collectively …

Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …

Protein coats are supramolecular complexes that assemble on the cytosolic face of
membranes to promote cargo sorting and transport carrier formation in the endomembrane …

Megakaryocyte-derived platelets and endothelial cells store their hemostatic cargo in α-and
δ-granules and Weibel-Palade bodies, respectively. These storage granules belong to the …

Blood vessels demonstrate a multitude of complex signaling programs that work in concert
to produce functional vasculature networks during development. A known, but less widely …

Hermansky–Pudlak syndrome (HPS) is characterized by defects of multiple tissue‐specific
lysosome‐related organelles (LROs), typically manifesting with oculocutaneous albinism or …

Abstract von Willebrand factor (VWF) is an essential hemostatic protein that is synthesized
and secreted by endothelial cells and stored in Weibel-Palade bodies (WPBs). The …

Adaptin proteins (APs) play a crucial role in intracellular cell trafficking. The 'classical'role of
APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins …

Background Treatment choices for individual patients with an inborn bleeding disorder are
increasingly challenging due to increasing options and rising costs for society. We have …

Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these …