Aspirin: the mechanism of action revisited in the context of pregnancy complications

AP Cadavid - Frontiers in immunology, 2017 - frontiersin.org
Aspirin is one of the most frequently used and cheapest drugs in medicine. It belongs to the
non-steroidal anti-inflammatory drugs with a wide range of pharmacological activities …

Regulation of PCSK9 by nutraceuticals

AA Momtazi, M Banach, M Pirro, N Katsiki… - Pharmacological …, 2017 - Elsevier
PCSK9 (proprotein convertase subtilisin kexin type 9) is a liver secretory enzyme that
regulates plasma low-density lipoprotein (LDL) cholesterol (LDL-C) levels through …

[HTML][HTML] COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches

AV Sorokin, SK Karathanasis, ZH Yang… - The FASEB …, 2020 - ncbi.nlm.nih.gov
The current coronavirus disease 2019 (COVID‐19) pandemic presents a global challenge
for managing acutely ill patients and complications from viral infection. Systemic …

Naturally occurring PCSK9 inhibitors

MP Adorni, F Zimetti, MG Lupo, M Ruscica, N Ferri - Nutrients, 2020 - mdpi.com
Genetic, epidemiological and pharmacological data have led to the conclusion that
antagonizing or inhibiting Proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces …

Comparison of the dietary omega-3 fatty acids impact on murine psoriasis-like skin inflammation and associated lipid dysfunction

AV Sorokin, H Arnardottir, M Svirydava, Q Ng… - The Journal of …, 2023 - Elsevier
Persistent skin inflammation and impaired resolution are the main contributors to psoriasis
and associated cardiometabolic complications. Omega-3 polyunsaturated fatty acids …

[HTML][HTML] COVID-19 enters the expanding network of apolipoprotein E4-related pathologies

K Gkouskou, T Vasilogiannakopoulou, E Andreakos… - Redox biology, 2021 - Elsevier
COVID-19 incidence and case fatality rates (CFR) differ among ethnicities, stimulating efforts
to pinpoint genetic factors that could explain these phenomena. In this regard, the …

[HTML][HTML] Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management

M Waiz, SS Alvi, MS Khan - EXCLI journal, 2022 - ncbi.nlm.nih.gov
Atherosclerotic cardiovascular disease (ASCVD) stands amongst the leading causes of
mortality worldwide and has attracted the attention of world's leading pharmaceutical …

Edible insect Locusta migratoria shows intestinal protein digestibility and improves plasma and hepatic lipid metabolism in male rats

M Ochiai, K Tezuka, H Yoshida, T Akazawa, Y Komiya… - Food Chemistry, 2022 - Elsevier
Although edible insect migratory locusts are considered sustainable food resources with
proteins and n-3 lipids, their physiological effects on lipid metabolism are not clarified. Here …

Specialized pro-resolving mediators as potential regulators of inflammatory macrophage responses in COVID-19

MG Balta, E Papathanasiou… - Frontiers in …, 2021 - frontiersin.org
The recent outbreak of SARS-CoV2 has emerged as one of the biggest pandemics of our
century, with outrageous health, social and economic consequences globally. Macrophages …

Preferential incorporation of administered eicosapentaenoic acid into thin-cap atherosclerotic plaques

T Sato, M Horikawa, S Takei, F Yamazaki… - … , and vascular biology, 2019 - Am Heart Assoc
Objective: n-3 polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA), have beneficial effects on atherosclerosis. Although specific …