Pulmonary fibrosis occurs in a variety of clinical settings, constitutes a major cause of
morbidity and mortality, and represents an enormous unmet medical need. However, the …

Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by
chronic oligoanovulation and hyperandrogenism and associated with insulin resistance …

Summarizing the status of drugs in the market and examining the trend of drug research and
development is important in drug discovery. In this study, we compared the drug targets and …

Oxindoles have been successfully α-alkylated under Cp* CoIII catalysis by a vast array of
secondary alcohols, including cyclic, acyclic, symmetrical, and unsymmetrical, to produce C …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing disease with disappointing
survival rate, and uneffective therapeutic progress has been made in the last few years …

Background Nintedanib is a new tyrosine kinase inhibitor and growth factor antagonist. It
can be used to treat idiopathic pulmonary fibrosis diseases. Nintedanib has poor solubility in …

Idiopathic pulmonary fibrosis is a nonmalignant disease, yet it carries a prognosis akin to, or
even worse than, many cancers. Until recently, lung transplantation has been the only …

Cancer treatments are increasingly focusing on the molecular mechanisms underlying the
oncogenic processes present in tumors of individual patients. Fibroblast growth factor …

Introduction: 2-Indolinone is a well-known aromatic heterocyclic organic compound. A lot of
work has been done on this bicyclic structure by academic and company researchers to …

All known splice isoforms of vascular endothelial growth factor A (VEGF-A) can bind to the
receptor tyrosine kinases VEGFR-1 and VEGFR-2. We focus here on VEGF-A121a and …