Nanopore-based sensors have established themselves as a prominent tool for solution-
based, single-molecule analysis of the key building blocks of life, including nucleic acids …

Nanopores in solid-state membranes are promising for a wide range of applications
including DNA sequencing, ultra-dilute analyte detection, protein analysis, and polymer data …

Single entity sensing is recently an area of tremendous interest in analytical chemistry, such
that it is possible to analyze single cells, single particles, and even single molecules. Among …

Plasmonic and nanopore sensors have separately received much attention for achieving
single‐molecule precision. A plasmonic “hotspot” confines and enhances optical excitation …

Solid-state nanopores are single-molecule sensors that hold great potential for rapid protein
and nucleic-acid analysis. Despite their many opportunities, the conventional ionic current …

Sequence identification of peptides and proteins is central to proteomics. Protein
sequencing is mainly conducted by insensitive mass spectroscopy because proteins cannot …

Nanopore sensors have received significant interest for the detection of clinically important
biomarkers with single-molecule resolution. These sensors typically operate by detecting …

Single‐molecule sensing technologies aim to detect and characterize single biomolecules,
but generally need labeling while the measurement times and throughput are severely …

Cell heterogeneity poses a formidable challenge for tumor theranostics, requiring high-
resolution strategies for intercellular bioanalysis between single cells. Nanoelectrode-based …

Imitating the signal transduction and transmembrane transport controlled by biological
channels in the cell membrane, artificial nanochannels with a similar capability of sensing …