Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

As the incidence of hepatobiliary diseases increases, we must improve our understanding of
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …

The basal position of fish in vertebrate phylogeny makes them very attractive for genomic
and functional comparative immunity studies. Adaptive immunity arose early in vertebrate …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

Defects in iron absorption and utilization lead to iron deficiency and overload disorders.
Adult mammals absorb iron through the duodenum, whereas embryos obtain iron through …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

The zebrafish (Danio rerio) is a powerful model organism for the study of vertebrate biology,
being well suited to both developmental and genetic analysis. Large-scale genetic screens …

The zebrafish is firmly established as a genetic model for the study of vertebrate blood
development. Here we have characterized the blood-forming system of adult zebrafish. Each …