Effect of antidepressant medications on semen parameters and male fertility

LA Beeder, MK Samplaski - International Journal of Urology, 2020 - Wiley Online Library
Antidepressant medications are commonly used in males of reproductive age for long‐term
treatment of depression, as well as other disorders. Although antidepressants are known to …

Redox metabolism modulation as a mechanism in SSRI toxicity and pharmacological effects

MG Ștefan, B Kiss, AC Gutleb, F Loghin - Archives of Toxicology, 2020 - Springer
Depressive disorders are amongst the greatest mental health challenges, with an increasing
number of patients being diagnosed each year. Though it has not yet been fully elucidated …

The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm

R Rahban, A Rehfeld, C Schiffer, C Brenker… - Human …, 2021 - academic.oup.com
STUDY QUESTION Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect
the function of human sperm? SUMMARY ANSWER The SSRI antidepressant Sertraline (eg …

Sulforaphane substantially impedes testicular ferroptosis in adult rats exposed to di-2-ethylhexyl phthalate through activation of NRF-2/SLC7A11/GPX-4 trajectory

MM Elseweidy, NG Harb, AA Ali, RMA El-Aziz… - Naunyn-Schmiedeberg's …, 2024 - Springer
Abstract Di-2-ethylhexyl phthalate (DEHP) is a common plasticizer with a deleterious impact
on testicular functionality and male fertility. Growing evidence implicates ferroptosis as one …

Antioxidant activity of Spirulina platensis alleviates doxorubicin-induced oxidative stress and reprotoxicity in male rats

NZH Eleiwa, AAA Galal, RM Abd El-Aziz… - Oriental Pharmacy and …, 2018 - Springer
Male infertility is a common side effect of doxorubicin (DOX) that substantially impairs the
quality of life of young cancer survivors. Therefore, the current work was designed to …

Food Yellow4 reprotoxicity in relation to localization of DMC1 and apoptosis in rat testes: Roles of royal jelly and cod liver oil

YHA Elewa, AAR Mohamed, AAA Galal… - Ecotoxicology and …, 2019 - Elsevier
Abstract Food Yellow 4 (FY4) is a lemon-yellow-colored synthetic organic azo dye, which is
used widely for imparting pleasant and attractive appearance to foods and cosmetics. The …

The adverse effects of psychotropic drugs as an endocrine disrupting chemicals on the hypothalamic-pituitary regulation in male

S Ilgin - Life sciences, 2020 - Elsevier
Adverse effects of drugs on male reproductive system can be categorized as pre-testicular,
testicular, and post-testicular. Pre-testicular adverse effects disrupt the hypothalamic …

Whole-body exposure to filtered fraction of diesel exhaust induced localized testicular damage through attenuated functional response of glutathione-s-transferase in …

S Sarkar, A Dontham, R Revand, A Kandpal… - Reproductive …, 2024 - Elsevier
The possible vulnerability of the male reproductive system to environmental pollutants such
as air pollution necessitates a thorough investigation of the underlying mechanisms involved …

Comparative effect of administration and discontinuation of sildenafil and/or clomipramine on the hepatic, cardiac and testicular tissues of male rats

SMA El‐Sheikh, NZ Eleiwa, GM Khairy… - Andrologia, 2021 - Wiley Online Library
In this study, we examined the adverse consequences of prolonged treatment with sildenafil
and/or clomipramine (CLO) on the hepatic, cardiac and testicular tissues of rats. Additionally …

Effects of escitalopram treatment and chronic mild stress induced from peripuberty on spermatic parameters of adult rats

LW Fischer, TB Mendes, JN Simas, M Nunes… - …, 2023 - Wiley Online Library
Background The prevalence of depression in adolescents has significantly increased
worldwide. Escitalopram is a selective serotonin reuptake inhibitor approved for treatment of …