Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
The neurobiology of psychedelic drugs: implications for the treatment of mood disorders
FX Vollenweider, M Kometer - Nature Reviews Neuroscience, 2010 - nature.com
After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent
advances in our understanding of the neurobiology of psychedelics, such as lysergic acid …
advances in our understanding of the neurobiology of psychedelics, such as lysergic acid …
Ketamine triggers a switch in excitatory neuronal activity across neocortex
The brain can become transiently disconnected from the environment while maintaining
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …
Thalamic regulation of switching between cortical representations enables cognitive flexibility
Interactions between the prefrontal cortex (PFC) and mediodorsal thalamus are critical for
cognitive flexibility, yet the underlying computations are unknown. To investigate …
cognitive flexibility, yet the underlying computations are unknown. To investigate …
GluN2A mediates ketamine-induced rapid antidepressant-like responses
T Su, Y Lu, C Fu, Y Geng, Y Chen - Nature Neuroscience, 2023 - nature.com
Ketamine was thought to induce rapid antidepressant responses by inhibiting GluN2B-
containing N-methyl-d-aspartic acid (NMDA) receptors (NMDARs), which presents a …
containing N-methyl-d-aspartic acid (NMDA) receptors (NMDARs), which presents a …
Tau pathology induces excitatory neuron loss, grid cell dysfunction, and spatial memory deficits reminiscent of early Alzheimer's disease
H Fu, GA Rodriguez, M Herman, S Emrani, E Nahmani… - Neuron, 2017 - cell.com
The earliest stages of Alzheimer's disease (AD) are characterized by the formation of mature
tangles in the entorhinal cortex and disorientation and confusion when navigating familiar …
tangles in the entorhinal cortex and disorientation and confusion when navigating familiar …
Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition
A single, low dose of ketamine evokes antidepressant actions in depressed patients and in
patients with treatment-resistant depression (TRD). Unlike classic antidepressants, which …
patients with treatment-resistant depression (TRD). Unlike classic antidepressants, which …
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology
The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset
Alzheimer's disease (AD). However, the reason APOE4 is associated with increased AD risk …
Alzheimer's disease (AD). However, the reason APOE4 is associated with increased AD risk …
A transient developmental window of fast-spiking interneuron dysfunction in a mouse model of Dravet syndrome
Dravet syndrome is a severe, childhood-onset epilepsy largely due to heterozygous loss-of-
function mutation of the gene SCN1A, which encodes the type 1 neuronal voltage-gated …
function mutation of the gene SCN1A, which encodes the type 1 neuronal voltage-gated …
Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
G Sanacora, MA Smith, S Pathak, HL Su… - Molecular …, 2014 - nature.com
Ketamine, an N-methyl-D-aspartate receptor (NMDAR) channel blocker, has been found to
induce rapid and robust antidepressant-like effects in rodent models and in treatment …
induce rapid and robust antidepressant-like effects in rodent models and in treatment …