Expanding the synthetic toolbox through metal–enzyme cascade reactions

S González-Granda, J Albarrán-Velo… - Chemical …, 2023 - ACS Publications
The combination of metal-, photo-, enzyme-, and/or organocatalysis provides multiple
synthetic solutions, especially when the creation of chiral centers is involved. Historically …

The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis

RA Sheldon, D Brady, ML Bode - Chemical science, 2020 - pubs.rsc.org
Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …

Challenges and opportunities in multicatalysis

S Martínez, L Veth, B Lainer, P Dydio - ACS Catalysis, 2021 - ACS Publications
Multicatalysis is an emerging field targeting the development of efficient catalytic
transformations to quickly convert relatively simple starting materials into more complex …

Nickel-catalyzed remote asymmetric hydroalkylation of alkenyl ethers to access ethers of chiral dialkyl carbinols

JW Wang, Z Li, D Liu, JY Zhang, X Lu… - Journal of the American …, 2023 - ACS Publications
Site-and enantio-selective alkyl–alkyl bond formation is privileged in the retrosynthetic
analysis due to the universality of sp3-hybridized carbon atoms in organic molecules …

Broadening the scope of biocatalysis in sustainable organic synthesis

RA Sheldon, D Brady - ChemSusChem, 2019 - Wiley Online Library
This Review is aimed at synthetic organic chemists who may be familiar with organometallic
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …

Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis

ZC Litman, Y Wang, H Zhao, JF Hartwig - Nature, 2018 - nature.com
Living organisms rely on simultaneous reactions catalysed by mutually compatible and
selective enzymes to synthesize complex natural products and other metabolites. To …

Constructing biocatalytic cascades: in vitro and in vivo approaches to de novo multi-enzyme pathways

SP France, LJ Hepworth, NJ Turner, SL Flitsch - Acs Catalysis, 2017 - ACS Publications
The combination of sequential biocatalytic reactions, via non-natural synthetic cascades, is a
rapidly developing field and leads to the generation of complex valuable chemicals from …

The Asymmetric Buchwald–Hartwig Amination Reaction

CJ Lu, Q Xu, J Feng, RR Liu - … Chemie International Edition, 2023 - Wiley Online Library
Over the past few decades, the Buchwald–Hartwig reaction has emerged as a powerful tool
for forging C− N bonds, and has been vital to the pharmaceuticals, materials, and catalysis …

The limits to biocatalysis: pushing the envelope

RA Sheldon, D Brady - Chemical communications, 2018 - pubs.rsc.org
In the period 1985 to 1995 applications of biocatalysis, driven by the need for more
sustainable manufacture of chemicals and catalytic,(enantio) selective methods for the …

N-Heterocyclic carbene-catalyzed enantioselective (dynamic) kinetic resolutions and desymmetrizations

Y Zhang, H Cai, X Gan, Z Jin - Science China Chemistry, 2024 - Springer
N-heterocyclic carbene-catalyzed enantioselective kinetic resolutions, dynamic kinetic
resolutions, and desymmetrization reactions are systematically reviewed. The content is …