The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Background Congenital disorders of glycosylation (CDG) are inherited metabolic diseases
caused by defects in the genes important for the process of protein and lipid glycosylation …

A transmembrane protein (TMEM) is a type of protein that spans biological membranes.
Many of them extend through the lipid bilayer of the plasma membrane but others are …

Galactose is an essential carbohydrate for cellular metabolism, as it contributes to energy
production and storage in several human tissues while also being a precursor for …

Glycosylated α-dystroglycan (α-DG) serves as cellular entry receptor for multiple pathogens,
and defects in its glycosylation cause hereditary Walker-Warburg syndrome (WWS). At least …

Lysosomal calcium (Ca2+) release is critical to cell signaling and is mediated by well-known
lysosomal Ca2+ channels. Yet, how lysosomes refill their Ca2+ remains hitherto …

The human solute carriers (SLCs) comprise over 400 different transporters, organized into
65 families (http://slc. bioparadigms. org/) based on their sequence homology and transport …

Conspectus DNA nanodevices are nanoscale assemblies, formed from a collection of
synthetic DNA strands, that may perform artificial functions. The pioneering developments of …

Nearly 70 inherited human glycosylation disorders span a breathtaking clinical spectrum,
impacting nearly every organ system and launching a family-driven diagnostic odyssey …

Exocytic and endocytic compartments each have their own unique luminal ion and pH
environment that is important for their normal functioning. A failure to maintain this …