Genetics of diabetes mellitus and diabetes complications
Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
Clinical utility of polygenic risk scores for coronary artery disease
D Klarin, P Natarajan - Nature Reviews Cardiology, 2022 - nature.com
Over the past decade, substantial progress has been made in the discovery of alleles
contributing to the risk of coronary artery disease. In addition to providing causal insights into …
contributing to the risk of coronary artery disease. In addition to providing causal insights into …
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …
onset—remains an important public health need. Prior studies have developed genome …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
Genome-wide polygenic score to predict chronic kidney disease across ancestries
Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression
The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
The functional interpretation of genome-wide association studies (GWAS) is challenging due
to the cell-type-dependent influences of genetic variants. Here, we generated …
to the cell-type-dependent influences of genetic variants. Here, we generated …
The nuclear receptor ESRRA protects from kidney disease by coupling metabolism and differentiation
Kidney disease is poorly understood because of the organ's cellular diversity. We used
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular …
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular …
Integrated multi-omics approaches to improve classification of chronic kidney disease
S Eddy, LH Mariani, M Kretzler - Nature Reviews Nephrology, 2020 - nature.com
Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …
associated comorbidities and pattern of injury on biopsy. Even within a given classification …