Pediatric central nervous system tumors are the most common solid malignancies in
childhood, and aggressive therapy often leads to long-term sequelae in survivors, making …

Glioblastoma multiforme is the most malignant of the primary brain tumours and is almost
always fatal. The treatment strategies for this disease have not changed appreciably for …

DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but
the selective pressure for their inactivation remains elusive,,. We analysed a panel of human …

Neural stem cells in the subventricular zone (SVZ) continue to generate new neurons in the
adult brain. SVZ cells exposed to EGF in culture grow to form neurospheres that are …

Medulloblastomas are brain tumors that arise in the cerebellum of children and contain stem
cells in a perivascular niche thought to give rise to recurrence following radiation. We used …

Astrocytic and oligodendroglial gliomas are intrinsic brain tumours characterized by
infiltrative growth and resistance to classic cancer therapies, which renders them inevitably …

Genetically engineered mouse models have contributed extensively to the field of cancer
research. The ability to manipulate the mouse germline affords numerous approaches …

β‐catenin is the major effector of the canonical Wnt signaling pathway. Mutations in
components of the pathway that stabilize β‐catenin result in augmented gene transcription …

The Kaposi's sarcoma herpesvirus (KSHV) has been identified as the etiologic agent of
Kaposi's sarcoma (KS), but initial events leading to KS development remain unclear …

The PML tumor suppressor controls key pathways for growth suppression, induction of
apoptosis, and cellular senescence. PML loss occurs frequently in human tumors through …