Biotransformation refers to the metabolic conversion of endogenous and xenobiotic
chemicals into more hydrophilic substances. Xenobiotic biotransformation is accomplished …

According to the free drug hypothesis (FDH), only free, unbound drug is available to interact
with biological targets. This hypothesis is the fundamental principle that continues to explain …

Induction of cytochrome P450 (CYP) genes constitutes an important cause of drug–drug
interactions and preclinical evaluation of induction liability is mandatory for novel drug …

Emerging advances in the field of in vitro toxicity testing attempt to meet the need for reliable
human-based safety assessment in drug development. Intrahepatic cholangiocyte …

Accurate prediction of human pharmacokinetics using in vitro tools is an important task
during drug development. Albeit, currently used in vitro systems for clearance extrapolation …

The oxidation of fats and oils is an undisputed subject of science, given the effect of oxidized
fats and oils on food quality and safety. This study aimed to determine whether maternal …

Breast cancer (BC) is a heterogenous disease, with prognosis and treatment options
depending on Estrogen, Progesterone receptor, and Human Epidermal Growth Factor …

Recent FDA approvals of mRNA vaccines, short-interfering RNAs, and antisense
oligonucleotides highlight the success of oligonucleotides as therapeutics. Aptamers are …

Aging, an inevitable physiological process leading to a progressive decline in bodily
functions, has been an abundantly researched domain with studies attempting to slow it …

Organotypic three‐dimensional liver spheroid cultures in which hepatic cells retain their
molecular phenotype and functionality have emerged as powerful tools for preclinical drug …