Deciphering tumour heterogeneity: from tissue to liquid biopsy
Simple Summary Most malignant tumours are highly heterogeneous at molecular and
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …
A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition
Triple-negative breast cancer (TNBC), a highly metastatic breast cancer subtype, has limited
treatment options. While a small number of patients attain clinical benefit with single-agent …
treatment options. While a small number of patients attain clinical benefit with single-agent …
Targeting interleukin-13 receptor α2 (IL-13Rα2) for glioblastoma therapy with surface functionalized nanocarriers
R Liang, C Wu, S Liu, W Zhao - Drug Delivery, 2022 - Taylor & Francis
Despite surgical and therapeutic advances, glioblastoma multiforme (GBM) is among the
most fatal primary brain tumor that is aggressive in nature. Patients with GBM have a median …
most fatal primary brain tumor that is aggressive in nature. Patients with GBM have a median …
[HTML][HTML] Nifuratel Induces Triple-Negative Breast Cancer Cell G2/M Phase Block and Apoptosis by Regulating GADD45A
Y Hou, H Hao, Y Yuan, J Zhang, Z Liu, Y Nie, S Zhang… - Pharmaceuticals, 2024 - mdpi.com
(1) Background: Nifuratel (NF113), derived from nitrofuran, has a specific anti-tumor effect.
However, the potential mechanisms of NF113 in triple-negative breast cancer remain …
However, the potential mechanisms of NF113 in triple-negative breast cancer remain …
Design, synthesis, and biological evaluation of cathepsin B cleavage albumin-binding SN38 prodrug in breast cancer
Y Lu, Y Huang, J Jin, J Yu, W Lu, S Zhu - Bioorganic Chemistry, 2024 - Elsevier
Here, we introduce a novel and effective approach utilizing a cathepsin B cleavage albumin-
binding SN38 prodrug specifically designed for the treatment of metastatic breast cancer …
binding SN38 prodrug specifically designed for the treatment of metastatic breast cancer …
[HTML][HTML] Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotype and phenotype in chronic lymphocytic leukemia
Bruton's tyrosine kinase (BTK) inhibitors are effective for the treatment of chronic lymphocytic
leukemia (CLL) due to BTK's role in B cell survival and proliferation. Treatment resistance is …
leukemia (CLL) due to BTK's role in B cell survival and proliferation. Treatment resistance is …
quickBAM: a parallelized BAM file access API for high-throughput sequence analysis informatics
Motivation In time-critical clinical settings, such as precision medicine, genomic data needs
to be processed as fast as possible to arrive at data-informed treatment decisions in a timely …
to be processed as fast as possible to arrive at data-informed treatment decisions in a timely …