Cancer is characterized by metabolic reprogramming, which is a hot topic in tumor treatment
research. Cancer cells alter metabolic pathways to promote their growth, and the common …

The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …

Cysteine is a conditionally essential amino acid required for the synthesis of proteins and
many important intracellular metabolites. Cysteine depletion can trigger iron‐dependent …

Gamma-glutamyl transpeptidase (GGT) is an enzyme located on the outer membrane of the
cells where it regulates the metabolism of glutathione (GSH), the most abundant intracellular …

Loss of the retinoblastoma (RB) tumor suppressor protein is a critical step in reprogramming
biological networks that drive cancer progression, although mechanistic insight has been …

Glutamate, as one of the most important carbon sources in the TCA cycle, is central in
metabolic processes that will subsequently influence tumor progression. Several factors can …

Glutamate is a pivotal excitatory neurotransmitter in mammalian brains, but excessive
glutamate causes numerous neural disorders. Almost all extracellular glutamate is retrieved …

RNA modification has emerged as an important epigenetic mechanism that controls
abnormal metabolism and growth in acute myeloid leukaemia (AML). However, the roles of …

Lobetyolin (LBT) is a polyacetylene glycoside found in diverse medicinal plants but mainly
isolated from the roots of Codonopsis pilosula, known as Radix Codonopsis or Dangshen …

Metabolic reprogramming is a key hallmark of cancer and shifts cellular metabolism to meet
the demands of biomass production necessary for abnormal cell reproduction. One-carbon …