Docking-based virtual screening and molecular dynamics simulations of quercetin analogs as enoyl-acyl carrier protein reductase (InhA) inhibitors of Mycobacterium …
The emergence of multidrug-resistant Mycobacterium tuberculosis (MTB) has become a
major problem in treating tuberculosis (TB) and shows the need to develop new and efficient …
major problem in treating tuberculosis (TB) and shows the need to develop new and efficient …
Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
DAE Pitaloka, Y Syaputri, P Nurlilasari… - Drug Design …, 2024 - Taylor & Francis
Tuberculosis (TB) stands as the second most prevalent cause of global human mortality from
infectious diseases. In 2022, the World Health Organization documented an estimated …
infectious diseases. In 2022, the World Health Organization documented an estimated …
Exploring the bioactivity of pentacyclic triterpenoids as potential antimycobacterial nutraceutics: Insights through comparative biomolecular modelling
A group of bioactive compounds known as triterpenoids, which are often found in plant
materials, have been tested to possess nutritional and pharmaceutical activity. These plant …
materials, have been tested to possess nutritional and pharmaceutical activity. These plant …
Regulation of mitogen-activated protein kinase signaling pathway and proinflammatory cytokines by ursolic acid in murine macrophages infected with Mycobacterium …
DAE Pitaloka, AM Cooper, AA Artarini… - Infectious disease …, 2020 - pmc.ncbi.nlm.nih.gov
Mycobacterium avium, one of the closest relatives of Mycobacterium tuberculosis (MTB),
offers an advantage in studying MTB because of its tuberculosis-like effect in humans and …
offers an advantage in studying MTB because of its tuberculosis-like effect in humans and …
[HTML][HTML] Discovery of potent triterpenoid and limonoid compounds targeting Mycobacterium tuberculosis enoyl acyl carrier protein reductase (InhA): An in silico …
Drug resistance remains one of the primary concerns in treating tuberculosis (TB), making it
imperative to find new and effective drug candidates for improved TB treatment. Enoyl acyl …
imperative to find new and effective drug candidates for improved TB treatment. Enoyl acyl …
Alpha-mangostin as an inhibitor of GSK3β in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a breast cancer subtype that does not express the
estrogen receptor, the progesterone receptor, or the human epidermal growth factor receptor …
estrogen receptor, the progesterone receptor, or the human epidermal growth factor receptor …
Design of new quinazoline derivative as EGFR (Epidermal growth factor receptor) inhibitor through molecular docking and dynamics simulation
Erlotinib, Afatinib, and WZ4002 are quinazoline derivative compounds and classified as first,
second, and third-generation EGFR inhibitor. All inhibitors have been given directly to …
second, and third-generation EGFR inhibitor. All inhibitors have been given directly to …
Molecular interactions of Andrographis paniculata Burm. f. Active Compound with Nuclear Receptor (CAR and PXR): An In Silico Assessment Approach
The study aims to analyze the potential Herb-Drug Interactions (HDIs) of the chemical
compound in Andrographis paniculate Burm. f. against Constitutive Androstane Receptor …
compound in Andrographis paniculate Burm. f. against Constitutive Androstane Receptor …
Anti-Inflammatory Activity of Quts Al-Hindi Extract (Saussurea Lappa) Using Erythrocyte Membrane Stability and Prediction of Its Selectivity for COX-2 and INOS …
An immune system reaction known as inflammation can damage tissue by rupturing mast
cells, followed by released inflammatory mediators such as nitric oxide (NO) and increased …
cells, followed by released inflammatory mediators such as nitric oxide (NO) and increased …