G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing
signals from the extracellular environment to the inside of the cell. They mediate the effects …

The tumor microenvironment (TME) is a complex interconnected network of immune cells,
fibroblasts, blood vessels, and extracellular matrix surrounding the tumor. Because of its …

Chemokine receptor CXCR4 is involved in diverse diseases. A comparative study was
conducted on CXCR4 embedded in a POPC lipid bilayer binding with CXCL12 in full and …

CXCR4 is a ubiquitously expressed chemokine receptor that regulates leukocyte trafficking
and arrest in both homeostatic and pathological states. It also participates in organogenesis …

Membrane proteins play essential roles in various biological functions within the cell. One of
the most common functional regulations involves the dimerization of two single-pass …

G protein-coupled receptors (GPCRs) are membrane proteins targeted by over one-third of
marketed drugs. Understanding their activation mechanism is essential for precise …

Dear Editor, Herpesviruses encode G protein-coupled receptors (GPCRs) in their viral
genomes and express these receptors in infected host cells to reprogram cell signaling …

Cancer remains a leading cause of mortality worldwide and calls for novel therapeutic
targets. Membrane proteins are key players in various cancer types but present unique …

Abstract G-Protein-Coupled Receptors (GPCRs) make up around 3–4% of the human
genome and are the targets of one-third of FDA-approved drugs. GPCRs typically exist as …

The chemokine receptor CXCR4 is overexpressed in many cancers and contributes to
pathogenesis, disease progression, and resistance to therapies. CXCR4 is known to form …