Tumor microenvironment contribution to checkpoint blockade therapy: lessons learned from Hodgkin lymphoma

A Carbone, A Gloghini… - Blood, The Journal of the …, 2023 - ashpublications.org
Classic Hodgkin lymphoma (cHL) is characterized by a tumor microenvironment (TME)
containing inflammatory/immune cells. Follicular lymphoma, mediastinal gray zone …

Testicular diffuse large b-cell lymphoma—clinical, molecular, and immunological features

M Pollari, SK Leivonen, S Leppä - Cancers, 2021 - mdpi.com
Simple Summary Testicular diffuse large B-cell lymphoma (T-DLBCL) is a rare and
aggressive lymphoma entity that mainly affects elderly men. It has a high relapse rate with …

[HTML][HTML] Identification of novel prognosis-related genes in the endometrial cancer immune microenvironment

J Ma, JK Zhang, D Yang, XX Ma - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
The incidence of endometrial cancer is increasing each year, and treatment effects are poor
for patients with advanced and specific subtypes. Exploring immune infiltration-related …

Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

M Granai, L Mundo, AU Akarca, MC Siciliano… - Infectious agents and …, 2020 - Springer
Abstract Background The Tumor Microenviroment (TME) is a complex milieu that is
increasingly recognized as a key factor in multiple stages of disease progression and …

T-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma

ZZ Yang, HJ Kim, H Wu, X Tang, Y Yu, J Krull… - Blood cancer …, 2023 - nature.com
T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL).
However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets …

Infiltration of CD163‐, PD‐L1‐and FoxP3‐positive cells adversely affects outcome in patients with mantle cell lymphoma independent of established risk factors

JM Rodrigues, A Nikkarinen… - British journal of …, 2021 - Wiley Online Library
We characterised patients with mantle cell lymphoma (MCL) with poor prognosis based on
differences in immune infiltration. Different expressions of the tumour cell markers Cyclin D1 …

Extracellular vesicles: new players in lymphomas

V Navarro-Tableros, Y Gomez, G Camussi… - International journal of …, 2018 - mdpi.com
Lymphomas are heterogeneous diseases, and the term includes a number of histological
subtypes that are characterized by different clinical behavior and molecular phenotypes …

[HTML][HTML] A four-methylated mRNA signature-based risk score system predicts survival in patients with hepatocellular carcinoma

Y Wang, Z Ruan, S Yu, T Tian, X Liang, L Jing… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Evidence suggests that altered DNA methylation plays a causative role in the pathogenesis
of various cancers, including hepatocellular carcinoma (HCC). Thus, methylated differently …

High levels of tim-3+ foxp3+ treg cells in the tumor microenvironment is a prognostic indicator of poor survival of diffuse large B cell lymphoma patients

W Zhong, X Liu, Z Zhu, Q Li, K Li - International immunopharmacology, 2021 - Elsevier
Foxp3+ Treg cells display phenotypic and functional heterogeneity, which express high
levels of T cell immunoglobulin and mucin-domain containing-3 (Tim-3) in the tumor …

Landscape of 4D cell interaction in Hodgkin and non-Hodgkin lymphomas

S Hartmann, S Scharf, Y Steiner, AG Loth… - Cancers, 2021 - mdpi.com
Simple Summary Little is known about the motility and interaction of primary human
lymphoma cells in lymph nodes. The aim of this study therefore was to analyze for the first …