Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract
Effective evaluation and prediction of aerosol transport deposition in the human respiratory
tracts are critical to aerosol drug delivery and evaluation of inhalation products …
tracts are critical to aerosol drug delivery and evaluation of inhalation products …
Tutorial: Understanding the transport, deposition, and translocation of particles in human respiratory systems using Computational Fluid-Particle Dynamics and …
Dynamic modeling of how particulate matter (PM) transport, deposit, and translocate from
human respiratory systems to systemic regions subject to indoor and outdoor exposures are …
human respiratory systems to systemic regions subject to indoor and outdoor exposures are …
Towards whole-lung simulations of aerosol deposition: A model of the deep lung
In silico methods can be used to estimate regional deposition of inhaled aerosols in regions
of the lung that are inaccessible by direct measurements. Knowledge of deposited dose is …
of the lung that are inaccessible by direct measurements. Knowledge of deposited dose is …
Analysis of flow field and turbulence predictions in a lung model applying RANS and implications for particle deposition
M Sommerfeld, OL Sgrott Jr, MA Taborda… - European Journal of …, 2021 - Elsevier
Airflow and aerosol deposition in the human airways are important aspects for applications
such as pulmonary drug delivery and human exposure to aerosol pollutants. Numerical …
such as pulmonary drug delivery and human exposure to aerosol pollutants. Numerical …
[HTML][HTML] Prediction of airway deformation effect on pulmonary air-particle dynamics: A numerical study
Most existing whole lung models neglect the airway deformation kinematics and assume the
lung airways are static. However, neglecting the airway deformation effect on pulmonary air …
lung airways are static. However, neglecting the airway deformation effect on pulmonary air …
An in silico inter-subject variability study of extra-thoracic morphology effects on inhaled particle transport and deposition
An understanding of human inter-subject variability is crucial for the implementation of
personalized pulmonary drug delivery as well as exposure assessment of airborne …
personalized pulmonary drug delivery as well as exposure assessment of airborne …
Polydisperse aerosol transport and deposition in upper airways of age-specific lung
A comprehensive understanding of airflow characteristics and particle transport in the
human lung can be useful in modelling to inform clinical diagnosis, treatment, and …
human lung can be useful in modelling to inform clinical diagnosis, treatment, and …
Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)
Despite the prevalence of inhalation therapy in the treatment of pediatric respiratory
disorders, most prominently asthma, the fraction of inhaled drugs reaching the lungs for …
disorders, most prominently asthma, the fraction of inhaled drugs reaching the lungs for …
Glottis motion effects on the particle transport and deposition in a subject-specific mouth-to-trachea model: A CFPD study
Abstract Background Computational Fluid-Particle Dynamics (CFPD) models have been
employed to predict lung aerosol dynamics for decades, estimating the delivery efficiency of …
employed to predict lung aerosol dynamics for decades, estimating the delivery efficiency of …
The effect of oral and nasal breathing on the deposition of inhaled particles in upper and tracheobronchial airways
The inhalation route has a substantial influence on the fate of inhaled particles. An outbreak
of infectious diseases such as COVID-19, influenza or tuberculosis depends on the site of …
of infectious diseases such as COVID-19, influenza or tuberculosis depends on the site of …