Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …

Drosophila neuroblasts, the stem cells of the developing fly brain, have emerged as a key
model system for neural stem cell biology and have provided key insights into the …

The ability of cells to divide asymmetrically is essential for generating diverse cell types
during development. The past 10 years have seen tremendous progress in our …

Throughout life, adult organs continually adapt to variable environmental factors. Adaptive
mechanisms must fundamentally differ from homeostatic maintenance, but little is known …

Stem cells are highly abundant during early development but become a rare population in
most adult organs. The molecular mechanisms causing stem cells to exit proliferation at a …

The lipid-sensing transcription factor PPARγ is the target of antidiabetic thiazolidinediones
(TZD). At two sites within its ligand binding domain, it also binds oxidized vitamin E …

Adult neurogenesis is often considered an archaic trait that has undergone a'phylogenetic
reduction'from amphibian ancestors to humans. However, adult neurogenesis in the …

Neural stem cells (NSCs) are found in two regions in the adult brain: the subgranular zone
(SGZ) in the hippocampal dentate gyrus and the subventricular zone (SVZ) adjacent to the …

During postembryonic life, hormones, including ecdysteroids, juvenile hormones, insulin-like
peptides, and activin/TGFβ ligands act to transform the larval nervous system into an adult …

Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane
misorganization drives oncogenic transcriptional events remains unclear. The polarity …