[PDF][PDF] Chromaffin cells of the adrenal medulla: physiology, pharmacology, and disease

E Carbone, R Borges, LE Eiden, AG García… - Compr …, 2019 - researchgate.net
Chromaffin cells (CCs) of the adrenal gland and the sympathetic nervous system produce
the catecholamines (epinephrine and norepinephrine; EPI and NE) needed to coordinate …

Roles of Na+, Ca2+, and K+ channels in the generation of repetitive firing and rhythmic bursting in adrenal chromaffin cells

CJ Lingle, PL Martinez-Espinosa, L Guarina… - … -European Journal of …, 2018 - Springer
Adrenal chromaffin cells (CCs) are the main source of circulating catecholamines (CAs) that
regulate the body response to stress. Release of CAs is controlled neurogenically by the …

Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists

AJ Hone, L Rueda‐Ruzafa, TJ Gordon… - Journal of …, 2020 - Wiley Online Library
Adrenal chromaffin cells release neurotransmitters in response to stress and may be
involved in conditions such as post‐traumatic stress and anxiety disorders. Neurotransmitter …

[HTML][HTML] Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland

A Pérez-Alvarez, A Hernández-Vivanco… - The FASEB …, 2012 - ncbi.nlm.nih.gov
In the present study, we have electrophysiologically characterized native nicotinic
acetylcholine receptors (nAChRs) in human chromaffin cells of the adrenal gland as well as …

Calcium entry through slow-inactivating L-type calcium channels preferentially triggers endocytosis rather than exocytosis in bovine chromaffin cells

JM Rosa, CJ Torregrosa-Hetland… - … of Physiology-Cell …, 2011 - journals.physiology.org
Calcium (Ca2+)-dependent endocytosis has been linked to preferential Ca2+ entry through
the L-type (α1D, CaV1. 3) of voltage-dependent Ca2+ channels (VDCCs). Considering that …

Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization‐elicited exocytosis in human chromaffin cells

A Pérez‐Alvarez, A Hernández‐Vivanco… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Expression of α7 nicotinic acetylcholine receptors
(nAChRs) and their role in exocytosis have not yet been examined in human chromaffin …

Human nicotinic receptors in chromaffin cells: characterization and pharmacology

A Albillos, JM McIntosh - Pflügers Archiv-European Journal of Physiology, 2018 - Springer
During the last 10 years, we have been working on human chromaffin cells obtained from
the adrenal gland of organ donors that suffered encephalic or cardiac death. We first …

Past, present and future of human chromaffin cells: role in physiology and therapeutics

A Pérez-Alvarez, A Hernández-Vivanco… - Cellular and molecular …, 2010 - Springer
Chromaffin cells are neuroendocrine cells mainly found in the medulla of the adrenal gland.
Most existing knowledge of these cells has been the outcome of extensive research …

Selectivity of action of pregabalin on Ca2+ channels but not on fusion pore, exocytotic machinery, or mitochondria in chromaffin cells of the adrenal gland

A Hernandez-Vivanco, A Perez-Alvarez… - … of Pharmacology and …, 2012 - ASPET
The present study was planned to investigate the action of pregabalin on voltage-dependent
Ca2+ channels (VDCCs) and novel targets (fusion pore formed between the secretory …

The firing frequency of spontaneous action potentials and their corresponding evoked exocytosis are increased in chromaffin cells of CCl4‐induced cirrhotic rats with …

S Sanz‐Lázaro, A Jiménez‐Pompa… - Journal of …, 2019 - Wiley Online Library
High catecolamine plasma levels because of sympathetic nervous system over‐activity
contribute to cirrhosis progression. The aim of this study was to investigate whether …