Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …

Neurofibromatosis 1 (NF1) is a multisystem disorder characterized by multiple café au lait
macules, intertriginous freckling, multiple cutaneous neurofibromas, and learning disability …

Abstract Neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and
schwannomatosis (SWN) are three clinically distinct tumor predisposition syndromes with a …

Abstract Neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and
schwannomatosis (SWN) are tumor-suppressor syndromes. Each syndrome is an orphan …

Abstract Background Plexiform neurofibromas (PNs) are benign peripheral nerve sheath
tumors that arise in one-third of individuals with neurofibromatosis type 1 (NF1). They may …

Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder (incidence 1: 33 000-
40 000) characterized by formation of central nervous system tumors, due to mutation in the …

We present a game-theoretic model of a polymorphic cancer cell population where the
treatment-induced resistance is a quantitative evolving trait. When stabilization of the tumor …

Neurofibromatosis 1 is a complex inherited neurocutaneous disease that is often difficult to
diagnose early because of its age-dependent presentation. The diagnosis is also extremely …

Objectives: The Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS)
International Collaboration Whole-Body MRI (WB-MRI) Working Group reviewed the existing …

Background There is scarce data on the quality of life of people with neurofibromatosis type
1 (NF1) and type 2 (NF2) in Canada. Methods A cross-sectional study of adults with NF1 and …