Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …

The prevalence of obesity has dramatically increased worldwide over the past decades.
Aging-related chronic conditions, such as type 2 diabetes and cardiovascular disease, are …

Rejuvenation of cells by reprogramming toward the pluripotent state raises increasing
attention. In fact, generation of induced pluripotent stem cells (iPSCs) completely reverses …

Partial cellular reprogramming via transient expression of Oct4, Sox2, Klf4, and c‐Myc
induces rejuvenation and reduces aged‐cell phenotypes. In this study, we found that …

Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …

The effects of environmental factors and epigenetics on health and disease development
are complex and interconnected. Environmental factors encompass external influences like …