Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …

Autophagy is a self-catabolic process through which cellular components are delivered to
lysosomes for degradation. There are three types of autophagy, ie, macroautophagy …

Abstract cGAS‐STING signalling is induced by detection of foreign or mislocalised host
double‐stranded (ds) DNA within the cytosol. STING acts as the major signalling hub, where …

The endosomal sorting complex required for transport (ESCRT) machinery evolved early in
evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed …

INTRODUCTION In response to aging, senescence plays a major role in the onset of various
degenerative diseases, including the slow development of cataracts, a clouding of the eye …

Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the
degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding …

Abstract ESCRTs (Endosomal Sorting Complex Required for Transports) are a modular set
of protein complexes with membrane remodeling activities that include the formation and …

Infantile striatonigral degeneration is caused by a homozygous variant of the nuclear‐pore
complex (NPC) gene NUP62, involved in nucleo‐cytoplasmic trafficking. By querying …

Background: Autophagy is a conserved physiological intracellular mechanism responsible
for the degradation and recycling of cytoplasmic constituents (eg, damaged organelles, and …

The use of standardised phenotyping screens to identify abnormal phenotypes in mouse
knockouts, together with the use of ontologies to describe such phenotypic features, allows …