Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

Malate-aspartate shuttle (MAS) is essential for maintaining glycolysis and energy
metabolism in tumors, while its regulatory mechanisms in neuroblastoma (NB), the …

Background: Per-and polyfluoroalkyl substances (PFASs) are persistent chemicals that
firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as …

G protein-coupled receptors (GPCRs) play a key role in regulating the homeostasis of the
internal environment and are closely associated with tumour progression as major …

Dose-limiting cardiotoxicity remains a major limitation in the clinical use of cancer
chemotherapeutics. Here, we describe a role for Regulator of G protein Signaling 7 (RGS7) …

As negative modulators of G-protein-coupled receptors (GPCRs) signaling, regulators of G
protein signaling (RGS) proteins facilitate various downstream cellular signalings through …

Single-cell DNA sequencing (scDNA-seq) methods are powerful tools for profiling mutations
in cancer cells; however, most genomic regions sequenced in single cells are non …

Signaling by the G-protein-coupled receptors (GPCRs) plays fundamental role in a vast
number of essential physiological functions. Precise control of GPCR signaling requires …