From the soil to the clinic: the impact of microbial secondary metabolites on antibiotic tolerance and resistance

EK Perry, LA Meirelles, DK Newman - Nature Reviews Microbiology, 2022 - nature.com
Secondary metabolites profoundly affect microbial physiology, metabolism and stress
responses. Increasing evidence suggests that these molecules can modulate microbial …

The role of extracellular DNA in the formation, architecture, stability, and treatment of bacterial biofilms

H Panlilio, CV Rice - Biotechnology and bioengineering, 2021 - Wiley Online Library
Advances in biotechnology to treat and cure human disease have markedly improved
human health and the development of modern societies. However, substantial challenges …

[HTML][HTML] Bacterial biofilm inhibitors: An overview

VC Kalia, SKS Patel, JK Lee - Ecotoxicology and Environmental Safety, 2023 - Elsevier
Bacteria that cause infectious diseases adopt biofilms as one of their most prevalent
lifestyles. Biofilms enable bacteria to tolerate environmental stress and evade antibacterial …

Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system

F Jean-Pierre, TH Hampton, D Schultz, DA Hogan… - Elife, 2023 - elifesciences.org
Interspecies interactions can drive the emergence of unexpected microbial phenotypes that
are not observed when studying monocultures. The cystic fibrosis (CF) lung consists of a …

Development of antibiofilm nanocomposites: Ag/Cu bimetallic nanoparticles synthesized on the surface of graphene oxide nanosheets

J Jang, JM Lee, SB Oh, Y Choi, HS Jung… - ACS applied materials …, 2020 - ACS Publications
There are numerous issues associated with bacteria, particularly biofilms, which exhibit a
strong resistance to antibiotics. This is currently considered an urgent global issue owing to …

Metabolite-Mediated Bacterial Antibiotic Resistance Revealed by Surface-Enhanced Raman Spectroscopy

W Wang, PJ Vikesland - Environmental Science & Technology, 2023 - ACS Publications
A prompt on-site, real-time method to detect bacterial antibiotic resistance is crucial for
controlling the spread of resistance. Herein, we report the use of surface-enhanced Raman …

Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms

CM VanDrisse, R Lipsh-Sokolik… - Proceedings of the …, 2021 - National Acad Sciences
Pseudomonas aeruginosa is an opportunistic human pathogen that develops difficult-to-
treat biofilms in immunocompromised individuals, cystic fibrosis patients, and in chronic …

A Potential High-Risk Clone of Pseudomonas aeruginosa ST463

Y Hu, W Peng, Y Wu, H Li, Q Wang, H Yi… - Frontiers in …, 2021 - frontiersin.org
Pseudomonas aeruginosa is one of the most common opportunistic pathogens, which
causes severe nosocomial infections because of its well-known multidrug-resistance and …

Resistance evolution can disrupt antibiotic exposure protection through competitive exclusion of the protective species

AM Quinn, MJ Bottery, H Thompson… - The ISME …, 2022 - academic.oup.com
Antibiotic degrading bacteria can reduce the efficacy of drug treatments by providing
antibiotic exposure protection to pathogens. While this has been demonstrated at the …

Citric Acid Confers Broad Antibiotic Tolerance through Alteration of Bacterial Metabolism and Oxidative Stress

XS Li, JZ Xue, Y Qi, I Muhammad, H Wang… - International Journal of …, 2023 - mdpi.com
Antibiotic tolerance has become an increasingly serious crisis that has seriously threatened
global public health. However, little is known about the exogenous factors that can trigger …