Folate receptors including folate receptor α (FRα) are overexpressed in up to 90% of ovarian
cancers. Ovarian cancers overexpressing FRα often exhibit high degrees of drug resistance …

This review highlights the role of computational chemistry, specifically quantum and
molecular mechanics, in the development of folate‐based anticancer drugs. Folate receptors …

Two different covalently linked phenyl-bridged 3-pyrrolyl BODIPY–BODIPY dyads were
synthesized through a series of synthetic steps and thoroughly characterized and studied …

The first examples of m-/p-phenylene bridged bis (3-pyrrolyl BODIPY) s were synthesized by
oxidizing the readily available m-/p-phenylene bridged bis (dipyrromethane) with DDQ in …

The endosome cleavable linkers have been widely employed by antibody-drug conjugates
and small molecule-drug conjugates (SMDCs) to control the accurate release of payloads …

Targeted delivery of chemotherapeutics to tumor cells is one of the biggest challenges in
cancer treatment. Herein, we synthesized smart dipeptide nanoparticles for cancer-specific …

Hetero-nanoparticles self-assembled from a conjugate bearing folic acid as the targeting
agent, and another bearing paclitaxel as the active agent are reported. Hetero-nanoparticles …

Cancer treatment continues to be a major challenge for the medical community mainly due
to non-specificity, leading to serious toxic effects. The use of vitamins such as folic acid and …

In this dissertation, a series of 18 F-labeled prostate-specific membrane antigen-(PSMA-)
and folate receptor-(FR-) targeting ligands exploiting the Silicon-based Fluoride Acceptor …